Institute
of Molecular Biology
and Biotechnology

Mission Statement:

IMBB is an internationally recognized and dynamic research organization aiming towards scientific excellence, international competitiveness and development of young scientists to contribute to healthcare  and agricultural progress.

Bioenergetics

Mitochondrial energy-dissipating pathways and mitochondria as a central hub in health, disease and adaptation to extreme conditions

Bioinformatics and Modelling

Computational analysis of genomes, integrative omics, biomolecular interactions, 3D modelling of biomolecules

Developmental Biology

Developmental neurobiology, developmental epigenetics, stem cell fate

Genome Biology

Meiotic recombination, epigenetics, DNA replication, genome folding and chromatin structure

Molecular Biology and Medicine

molecular and cellular biology, human molecular genetics, gene therapy, stem cell therapy, plant biotechnology

RNA Biology

RNA processing, RNA biochemistry, RNA transcription, RNA translation, RNA toxicity

News

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Seminars

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Selected publications

Ultrafast and accurate sequence alignment and clustering of viral genomes

Zielezinski A, Gudyś A, Barylski J, Siminski K, Rozwalak P, Dutilh BE & Deorowicz S

Autism-related traits in myotonic dystrophy type 1 model mice are due to MBNL sequestration and RNA mis-splicing of autism-risk genes

Sznajder LJ, Khan M, Ciesiołka A, Tadross M, Nutter CA, Taylor K, Pearson CE, Lewis MH, Hines RM, Swanson MS, Sobczak K & Yuen RKC

Genetic dissection of MutL complexes in Arabidopsis meiosis

Kbiri N, Fernández-Jiménez N, Dziegielewski W, Sáez-Zárate E, Pelé A, Mata-Villanueva A, Dluzewska J, Santos JL, Pradillo M, Ziolkowski PA

ETVs dictate hPSC differentiation by tuning biophysical properties

Ziojła NM, Socha M, Guerra MC, Kizewska D, Blaszczyk K, Urbaniak E, Henry S, Grabowska M, Niakan KK, Warmflash A & Borowiak M

Defining gene ends: RNA polymerase II CTD threonine 4 phosphorylation marks transcription termination regions genome-wide

Kopczyńska M, Saha U, Romanenko A, Nojima T, Gdula MR, Kamieniarz-Gdula K

The kinase ATR controls meiotic crossover distribution at the genome scale in Arabidopsis

Zhu L, Dluzewska J, Fernández-Jiménez N, Ranjan R, Pelé A, Dziegielewski W, Szymanska-Lejman M, Hus K, Górna J, Pradillo M, Ziolkowski PA

MBNL splicing factors regulate the microtranscriptome of skeletal muscles

Piasecka A, Szcześniak MW, Sekrecki M, Kajdasz A, Sznajder ŁJ, Baud A, Sobczak K

Pseudouridine guides germline small RNA transport and epigenetic inheritance

Herridge RP, Dolata J, Migliori V, Alves CdS, Borges F, Schorn AJ, van Ex F, Lin A, Bajczyk M, Parent J-S, Leonardi T, Hendrick A, Kouzarides T & Martienssen RA

Novel function of U7 snRNA in the repression of HERV1/LTR12s and lincRNAs in human cells

Plewka P, Szczesniak MW, Stepien A, Pasieka R, Wanowska E, Makalowska I, Raczynska KD

Ultraconserved bacteriophage genome sequence identified in 1300-year-old human palaeofaeces

Rozwalak P, Barylski J, Wijesekara Y, Dutilh BE, Zielezinski A

MSH2 stimulates interfering and inhibits non-interfering crossovers in response to genetic polymorphism

Dluzewska J, Dziegielewski W, Szymanska-Lejman M,Gazecka M, Henderson IR, Higgins JD & Ziolkowski PA

The effect of DNA polymorphisms and natural variation on crossover hotspot activity in Arabidopsis hybrids

Szymanska-Lejman M, Dziegielewski W, Dluzewska J, Kbiri N, Bieluszewska A, R. Scott Poethig RS & Ziolkowski PA

Chromatin-associated microprocessor assembly is regulated by the U1 snRNP auxiliary protein PRP40

Stepien A, Dolata J, Gulanicz T, Bielewicz D, Bajczyk M, Smolinski DJ, Szweykowska-Kulinska Z, Jarmolowski A

R-loops at microRNA encoding loci promote co-transcriptional processing of pri-miRNAs in plants

Gonzalo L, Tossolini I, Gulanicz T, Cambiagno DA, Kasprowicz-Maluski A, Smolinski DJ,  Mammarella MF, Ariel FD, Marquardt S, Szweykowska-Kulinska Z, Jarmolowski A & Manavella PA

Human pancreatic microenvironment promotes β-cell differentiation via non-canonical WNT5A/JNK and BMP signaling

Chmielowiec J, Szlachcic W, Yang D, Scavuzzo M, Wamble K, Sarrion-Perdigones A, Sabek O, Venken K & Borowiak M

NuA4 and H2A.Z control environmental responses and autotrophic growth in Arabidopsis

Bieluszewski T, Sura W, Dziegielewski W, Bieluszewska A, Lachance C, Kabza M, Szymanska-Lejman M, Abram M, Wlodzimierz P, De Winne N, De Jaeger G, Sadowski J, Côté J & Ziolkowski PA

PHIST: fast and accurate prediction of prokaryotic hosts from metagenomic viral sequences

Zielezinski A, Deorowicz S, Gudyś A

Bacterial Chaperone Protein Hfq Facilitates the Annealing of Sponge RNAs to Small Regulatory RNAs

Małecka EM, Sobańska D, Olejniczak M

Cyclic mismatch binding ligands interact with disease-associated CGG trinucleotide repeats in RNA and suppress their translation

Konieczny P, Mukherjee S, Stepniak-Konieczna E, Taylor K, Niewiadomska D, Piasecka A, Walczak A, Baud A, Dohno C, Nakatani K, Sobczak K

Natural variation identifies SNI1, the SMC5/6 component, as a modifier of meiotic crossover in Arabidopsis

Zhu L, Fernández-Jiménez N, Szymanska-Lejman M, Pelé A, Underwood CJ, Serra H, Lambing C, Dluzewska J, Bieluszewski T, Pradillo M, Henderson IR and Ziolkowski PA

Short antisense oligonucleotides alleviate the pleiotropic toxicity of RNA harboring expanded CGG repeats

Derbis M, Kul E, Niewiadomska D, Sekrecki M, Piasecka A, Taylor K, Hukema RK, Stork O & Sobczak K

mRNA adenosine methylase (MTA) deposits m6A on pri-miRNAs to modulate miRNA biogenesis in Arabidopsis thaliana

Sagar Bhat S, Bielewicz D, Gulanicz T, Bodi Z, Yu X, Anderson SJ, Szewc L, Bajczyk M, Dolata J, Grzelak N, Smolinski DJ, Gregory BD, Fray RG, Jarmolowski A, and Szweykowska-Kulinska Z

AON-induced splice-switching and DMPK pre-mRNA degradation as potential therapeutic approaches for Myotonic Dystrophy type 1

Stepniak-Konieczna E, Konieczny P, Cywoniuk P, Dluzewska J, Sobczak K

Determinants of RNA recognition by the FinO domain of the Escherichia coli ProQ protein

Stein EM, Kwiatkowska J, Basczok MM, Gravel CM, Berry KE, Olejniczak M

MSH2 shapes the meiotic crossover landscape in relation to interhomolog polymorphism in Arabidopsis

Alexander R Blackwell, Julia Dluzewska, Maja Szymanska‐Lejman, Stuart Desjardins, Andrew J Tock, Nadia Kbiri, Christophe Lambing, Emma J Lawrence, Tomasz Bieluszewski, Beth Rowan, James D Higgins, Piotr A Ziolkowski, Ian R Henderson

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Institute in numbers

Research groups

Employes

PhD students

Projects since 2014

Publications since 2014

Selected projects

ERC Starting Grant

dr hab. Kinga Kamieniarz-Gdula

EMBO Installation Grant

dr hab. Kinga Kamieniarz-Gdula

Prot-RAN Grant

dr Anna Baud