Laboratory of Biotechnology | Institute of Molecular Biology and Biotechnology

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Biotechnology Research Unit

The Lab’s aim is to investigate the regulation of plant signaling pathways with a focus on the roles of posttranslational modifications in this process particularly ubiquitination, sumoylation, and phosphorylation/dephosphorylation.

Prof. AMU Agnieszka Ludwików

Principal Investigator

Research

The phytohormone abscisic acid (ABA) plays a fundamental role in plant development, retrograde signalling, and plant adaptation to stress. Numerous ABA signalling effectors have been identified in all cell compartments. In our work we focus on MAP and SnRNK2 kinases, protein phosphatases type 2C (clade A PP2C), WHIRLY and BRO-like proteins. Our research aim is to uncover their biological functions and regulation at transcriptional and posttranscriptional level. We are interested how posttranslational modifications modulate their activity, turnover, localisation, or protein-protein interactions.
To achieve the aim, we use proteomic approaches including mass spectrometry and crystallography combined with biochemistry, molecular biology, bioinformatics, and small compound inhibitor design.