Dr Daria Niewiadomska, in collaboration with Prof. Krzysztof Sobczak, has investigated the role of FMR1 mRNA structure in regulating the non-canonical translation of the toxic polyglycine-containing protein, FMRpolyG, in the context of Fragile X premutation-associated conditions (FXPAC).
A breakthrough of this study is the demonstration, for the first time, that FMRpolyG stability depends on the number of CGG repeats in the FMR1 transcript.
Out now in Nucleic Acids Research! 🔬🧬
https://doi.org/10.1093/nar/gkag569
