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Omics Diabetes Group
Our lab’s aim is to integrate different levels of omics data information to decipher the mechanisms behind the development of pancreatic b-cells and their defects in diabetes (Polonez Bis 1 project).
Maciej Maurycy Łałowski, PhD, DSc, Docent
Principal Investigator
Research
With new lines of personalized medicine emerging, there is a growing demand to understand the specific disease mechanisms as well as to identify the prospective biomarkers to stratify patients and to monitor their treatment. The use of multiple omics technologies towards various forms of diabetes carries the potential to address such needs. The Polonez Bis project is realized in close collaboration with the host laboratory of Prof. Malgorzata Borowiak and her team at the AMU. By combing the expertise of the host institution with multiomics data integration expertise brought by the PI we propose to analyse the global changes at RNA, protein and metabolite level in control and patient developing pancreatic cells to build a dynamic map of changes in type 2 diabetes (T2D). Our main approaches are based on NGS (RNAseq), combined with mass spectrometry. We use both experimental and computational approaches.
Selected publications
- Laakkonen E, Soliymani R, Rintala P, Sipilä S, Kaprio J, Kujala U, Baumann M, Kovanen V, Lalowski M. Proteomic analysis of skeletal muscle reveals estrogen as a key regulator of muscle signaling in women. Aging Cell. 2017 Dec;16(6):1276-1287. doi: 10.1111/acel.12661
- Hulmi JJ, Penna F, Pöllänen N, Nissinen TA, Hentilä J, Lautaoja JH, Ballarò R, Soliymani R, Baumann M, Ritvos O, Pirinen E, Lalowski M. Increased muscle Serpina3n and NAD+depletion are molecular determinants of cancer cachexia – the effects of blocking myostatin/activins. 2020, Mol Metabolism, 2020 Jun 26;41:101046. doi: 10.1016/j.molmet.2020.101046
- Kankuri E, Finckenberg, Leinonen J, Tarkia M, Björk S, Purhonen J, Kallijärvi J, Kankainen M, Soliymani R, Lalowski M, Mervaala E. Altered acylcarnitine metabolism and inflexible mitochondrial fuel utilization characterize the loss of neonatal myocardial regeneration capacity. Exp Mol Medicine, 2023, . doi: 10.1038/s12276-023-00967-5
- Scavuzzo MA, Borowiak M. Two drugs converged in a pancreatic β cell. 2020, Science Translational Medicine 12;530. doi: 10.1126/scitranslmed.aba7359
- Yang D, Patel S, Szlachcic WJ, Chmielowiec J, Scaduto D, Putluri N, Sreekumar A, Suliburk J, Metzker M, Balasubramanyam A, Borowiak M. Pancreatic Differentiation of Stem Cells Reveals Pathogenesis of a Syndrome of Ketosis-Prone, 2021, Diabetes 70;10;2419-2429. doi: 10.2337/DB20-1293
- Chmielowiec J, Szlachcic WJ, Yang D, Scavuzzo MA, Wamble K, Sarrion-Perdigones A, Sabek OM, Venken K.JT, Borowiak M. Human pancreatic microenvironment promotes β-cell differentiation via non-canonical WNT5A/JNK and BMP signaling, 2022, Nature Communications, 13;1;1952. doi: 10.1038/s41467-022-29646-1
- Sikorski V, Selberg S, Lalowski M, Karelson M, Kankuri E. The structure and function of YTHDF epitranscriptomic m6A readers. Trends Pharmacol Sci. 2023 Jun;44(6):335-353. doi: 10.1016/j.tips.2023.03.004
Current group members
Maciej Maurycy Łałowski, PhD, DSc, Docent
principal investigator
Edyta Urbaniak, MSc
PhD student
Maja Bagińska, BSc
MSc student
Artur Jankowski, PhD
lab manager/research assistant