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Gene Expression

Our lab is working on gene expression regulation in plants. Specific emphasis is given to transcriptional and posttranscriptional regulation of microRNA biogenesis and microRNA function. Model plants as well as crop plants are studied.

Selected publications

1. SERRATE: a key factor in coordinated RNA processing in plants. Jozwiak M, Bielewicz D, Szweykowska-Kulinska Z, Jarmolowski A, Bajczyk M. Trends Plant Sci 2023.:S1360-1385(23)00089-4. doi: 10.1016/j.tplants.2023.03.009
2. MicroRNA172b-5p/trehalose-6-phosphate synthase module stimulates trehalose synthesis and microRNA172b-3p/AP2-like module accelerates flowering in barley upon drought stress. (2023) Swida-Barteczka A, Pacak A, Kruszka K, Nuc P, Karlowski WM, Jarmolowski A, Szweykowska-Kulinska Z. Front Plant Sci 2023.;14:1124785. doi: 10.3389/fpls.2023.1124785.
3. Chromatin-associated microprocessor assembly is regulated by the U1 snRNP auxiliary protein PRP40. Stepien A, Dolata J, Gulanicz T, Bielewicz D, Bajczyk M, Smolinski DJ, Szweykowska-Kulinska Z, Jarmolowski A. Plant Cell 2022.;34(12):4920-4935. doi: 10.1093/plcell/koac278.
4. Biogenesis, conservation, and function of miRNA in liverworts. () Pietrykowska H, Sierocka I, Zielezinski A, Alisha A, Carrasco-Sanchez JC, Jarmolowski A, Karlowski WM, Szweykowska-Kulinska Z. J Exp Bot 2022.;73(13):4528-4545. doi: 10.1093/jxb/erac098.
5. R-loops at microRNA encoding loci promote co-transcriptional processing of pri-miRNAs in plants. Gonzalo L, Tossolini I, Gulanicz T, Cambiagno DA, Kasprowicz-Maluski A, Smolinski DJ, Mammarella MF, Ariel FD, Marquardt S, Szweykowska-Kulinska Z, Jarmolowski A, Manavella PA. Nat Plants 2022.:402-418. doi: 10.1038/s41477-022-01125-x.
6. mRNA adenosine methylase (MTA) deposits m6A on pri-miRNAs to modulate miRNA biogenesis in Arabidopsis thaliana. Bhat SS, Bielewicz D, Gulanicz T, Bodi Z, Yu X, Anderson SJ, Szewc L, Bajczyk M, Dolata J, Grzelak N, Smolinski DJ, Gregory BD, Fray RG, Jarmolowski A, Szweykowska-Kulinska Z. Proc Natl Acad Sci U S A. 2020; 117(35):21785-21795. doi: 10.1073/pnas.2003733117
7. SERRATE interacts with the nuclear exosome targeting (NEXT) complex to degrade primary miRNA precursors in Arabidopsis. () Bajczyk M, Lange H, Bielewicz D, Szewc L, Bhat SS, Dolata J, Kuhn L, Szweykowska-Kulinska Z, Gagliardi D, Jarmolowski A. Nucleic Acids Res 2020.;48(12):6839-6854. doi: 10.1093/nar/gkaa373
8. Active 5′ splice sites regulate the biogenesis efficiency of Arabidopsis microRNAs derived from intron-containing genes. Knop K, Stepien A, Barciszewska-Pacak M, Taube M, Bielewicz D, Michalak M, Borst JW, Jarmolowski A, Szweykowska-Kulinska Z. (2017) Nucleic Acids Res.; 45(5):2757-2775. doi: 10.1093/nar/gkw895
9. Arabidopsis microRNA expression regulation in a wide range of abiotic stress responses. Barciszewska-Pacak M, Milanowska K, Knop K, Bielewicz D, Nuc P, Plewka P, Pacak AM, Vazquez F, Karlowski W, Jarmolowski A, Szweykowska-Kulinska Z. Front Plant Sci 2015.;6:410. doi: 10.3389/fpls.2015.00410.
10. Down-regulation of CBP80 gene expression as a strategy to engineer a drought-tolerant potato. Pieczynski M, Marczewski W, Hennig J, Dolata J, Bielewicz D, Piontek P, Wyrzykowska A, Krusiewicz D, Strzelczyk-Zyta D, Konopka-Postupolska D, Krzeslowska M, Jarmolowski A, Szweykowska-Kulinska Z. Plant Biotechnol J 2013.;11(4):459-69. doi: 10.1111/pbi.12032.